Chris Petrilli likes Seaside quite a bit:
I’ve been playing with Avi Bryant’s continuation-based web framework Seaside, which is written in Smalltalk. Wow. That’s all I can say. After some recent work with Rails, I had come to admire the cleanliness of the framework -- even if, on occasion, I had some complaints about short-cuts taken that need not be necessary. Compared to Seaside, Rails seems to me to be a jalopy. Don’t get me wrong, it’s a seriously pimped out jalopy, but the easy with which one can build interactivity and modify it on the fly with Seaside is mind-blowing.
Now, he does have some concerns about database interfacing - MySQL in particular. MySQL is a database that we are looking at seriously.