On weekends, we tend to play a lot pf boardgames with friends. We used to do a lot of role playing - I have my own game system even. That gradually ended though - it turned out that most of the wives like D&D style games a lot less than the husbands did. So we took to playing board games a long while back.
For a long while, we played a lot of Cosmic Encounter. My wife especially likes this game; it's got a lot of randomness. We got tired of that though, and found a lot of other great games - we spent a long time playing Settlers of Catan and it's various variants. We still play a lot of that - it's a game that stands the test of time.
What we have been playing recently is Puerto Rico. This is a truly great game. It moves quickly, and players get an action on every turn - you never really wait for the other players. At this point, we are playing a lot because I've won the last 4 or 5 games in a row - typically by one or two points - over my friend Mike. He's vowed to keep playing the game until he wins.
I highly recommend this game - it plays well, is very well balanced - and seems to play differently each time out.